Using protein QTL to disentangle variants effecting protein percentage in milk near the casein complex — ASN Events
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  2. Concurrent 6 - Detecting casual variants I
  3. Using protein QTL to disentangle variants effecting protein percentage in milk near the casein complex

Using protein QTL to disentangle variants effecting protein percentage in milk near the casein complex (#34)

Kathryn Kemper 1 , Mick Carrick 2 , Mike Goddard 1 3
  1. Faculty of Veterinary & Agricultural Sciences, University of Melbourne, Parkville, VIC, Australia
  2. Bergan Carrick Consultuing, Moonee Ponds, VIC, Australia
  3. Dept. of Economic Dev., Jobs, Transport and Resources, Bundoora, VIC, Australia

Casein proteins comprise about 80% of the protein in bovine milk.  The casein complex occupies a 300 kb region of the genome on BTA6.  To disentangle the number of variants affecting protein percentage in bovine milk near the casein complex, we use single variant regressions with imputed full sequence variants and quantified αS1-, β- and κ-casein protein levels in 444 Holstein Friesian cows.    We find 2 variants, located near CSN3 (coding κ-casein) and within CSN1S1 (which codes for αS1-casein), with independent effects on P% and which affect concentration of their corresponding casein gene products.  Previously described  protein polymorphisms in the casein genes were sometimes associated with the quantity of their respective proteins but it seems unlikely that these variants are causing variation in casein concentrations.

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